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New preclinical research from a group at the University of Texas, Dallas recommends that limiting blood glucose levels through the keto diet plan might prevent cancer.

To come to this conclusion, scientists limited circulating glucose in mice with lung cancer by feeding them a ketogenic diet, which contains hardly any sugar. They also gave the mice a diabetes drug that prevents blood glucose from being reabsorbed into the kidneys.

The ketogenic diet plan includes high fat foods, foods which contain a sufficient amount of protein, and an extremely low quantity of carbs.

Usually, the human body gets its primary source of energy (sugar) from carbohydrates.

Nevertheless, the ketogenic diet plan denies the body of glucose, inducing a state of "ketosis.".

During ketosis, the body is required to break down stored fat rather of sugar to produce an alternative source of energy.

The ketogenic, or "keto," diet has been around for centuries. Generally, some have utilized it as a therapy for conditions such as diabetes and epilepsy.

Newer studies have actually started to examine the healing capacity of the keto diet for other conditions, such as cancer, polycystic ovary syndrome, and Alzheimer's illness.

" Both the ketogenic diet and the medicinal restriction of blood glucose by themselves inhibited the more growth of squamous cell carcinoma growths in mice with lung cancer," stated matching author Dr. Jung-Whan "Jay" Kim, an assistant teacher of biological sciences at UT Dallas, per the research study published in Cell Reports. "While these interventions did not shrink the tumors, they did keep them from progressing, which suggests this type of cancer may be susceptible to glucose constraint.".

Lots of types of cancer cells are thought to be reliant on glucose (sugar) for their energy supply. However, as Kim and his colleagues found, one particular kind of cancer, squamous cell carcinoma, is more reliant than others.

" The key finding of our brand-new research study in mice is that a ketogenic diet plan alone does have some tumor-growth inhibitory effect in squamous cell cancer," Kim stated. "When we integrated this with the diabetes drug and chemotherapy, it was a lot more reliable.".

It ought to be kept in mind that glucose restriction did not have any effect on non-squamous-cell cancers. "Our outcomes recommend that this technique is cancer-cell-type particular. We can not generalize to all types of cancer," Kim stated.

Kim and his team also evaluated glucose levels in blood samples drawn from 192 clients affected by either lung or esophageal squamous cell cancer, along with 120 clients with lung adenocarcinoma. These blood samples were categorized into those containing glucose concentrations greater or lower than 120 mg/L-- one scientific measure of diabetes. None of the clients were detected with diabetes.

" Surprisingly, we discovered a robust correlation in between greater blood-glucose concentration and worse survival amongst clients with squamous cell cancer," Kim stated. "We found no such correlation amongst the lung adenocarcinoma clients. This is an essential observation that further links the potential effectiveness of glucose constraint in attenuating squamous-cell cancer development.".

Naturally, more clinical research studies are required to identify if glucose limitation is an effective cancer treatment, but the results he and his team discovered are still appealing.

" Manipulating host glucose levels would be a new technique that is different from simply trying to eliminate cancer cells directly," Kim stated. "I believe this belongs to a paradigm shift from targeting cancer cells themselves. Immunotherapy is a fine example of this, where the human immune system is activated to pursue cancer cells.".

" Maybe we can manipulate our own biological system a little bit or activate something we currently have in place in order to more effectively fight cancer.".